Clomipramine and Paroxetine Interaction
Drug interaction information between Clomipramine and Paroxetine.
Clomipramine and Paroxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clomipramine and Paroxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paroxetine blocks the liver enzyme responsible for breaking down clomipramine. This makes clomipramine stay in your body longer and reach higher levels.
FDA Label Information
While all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline, paroxetine, and fluvoxamine, inhibit P450 2D6, they may vary in the extent of inhibition.
Clomipramine Also Interacts With
- Sertraline minor
- Fluoxetine minor
- Methylphenidate minor
- Clonidine minor
- Warfarin minor
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Clomipramine + Paroxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Clomipramine's 15. In the minor band specifically: Clomipramine has 15 (also Sertraline, Fluoxetine, Methylphenidate, Clonidine); Paroxetine has 44 (also Buspirone, Clopidogrel, Aspirin, Venlafaxine).
What mechanism field is on file for Clomipramine and Paroxetine?
Paroxetine blocks the liver enzyme responsible for breaking down clomipramine. This makes clomipramine stay in your body longer and reach higher levels.
Paroxetine carries more major-labeled pairs than Clomipramine
SPL source-record counts only. This page's band is minor · classes on file: Clomipramine (Tricyclic Antidepressant (TCA)); Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Paroxetine has 3 major-labeled pairs vs Clomipramine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 15 minor · 15 total
- Other minor peers for Clomipramine
- Sertraline
- Fluoxetine
- Methylphenidate
- Clonidine
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Clopidogrel
- Aspirin
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.