Clomipramine and Fluoxetine Interaction
Drug interaction information between Clomipramine and Fluoxetine.
Clomipramine and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clomipramine and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine slows down the liver's process for clearing clomipramine from your body. This can lead to higher and potentially unsafe levels of clomipramine.
FDA Label Information
The plasma concentration of CMI has been reported to be increased by the concomitant administration of haloperidol; plasma levels of several closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of methylphenidate or hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decreased by the concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and such an effect may be anticipated with CMI as well. While all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline,...
Clomipramine Also Interacts With
- Sertraline minor
- Methylphenidate minor
- Paroxetine minor
- Clonidine minor
- Warfarin minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Clomipramine + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Clomipramine's 15. In the minor band specifically: Clomipramine has 15 (also Sertraline, Methylphenidate, Paroxetine, Clonidine); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Clomipramine and Fluoxetine?
Fluoxetine slows down the liver's process for clearing clomipramine from your body. This can lead to higher and potentially unsafe levels of clomipramine.
Fluoxetine carries more major-labeled pairs than Clomipramine
SPL source-record counts only. This page's band is minor · classes on file: Clomipramine (Tricyclic Antidepressant (TCA)); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Clomipramine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 15 minor · 15 total
- Other minor peers for Clomipramine
- Sertraline
- Methylphenidate
- Paroxetine
- Clonidine
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.