Clomipramine and Warfarin Interaction
Drug interaction information between Clomipramine and Warfarin.
Clomipramine and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clomipramine and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs compete for the same spots on proteins in your blood. This can cause more warfarin to stay active in your system, which might increase the risk of side effects.
FDA Label Information
Because clomipramine hydrochloride capsule, USP is highly bound to serum protein, the administration of clomipramine hydrochloride capsules, USP to patients taking other drugs that are highly bound to protein (e.g., warfarin, digoxin) may cause an increase in plasma concentrations of these drugs, potentially resulting in adverse effects.
Clomipramine Also Interacts With
- Sertraline minor
- Fluoxetine minor
- Methylphenidate minor
- Paroxetine minor
- Clonidine minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Clomipramine + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Clomipramine's 15. In the minor band specifically: Clomipramine has 15 (also Sertraline, Fluoxetine, Methylphenidate, Paroxetine); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Clomipramine and Warfarin?
Both drugs compete for the same spots on proteins in your blood. This can cause more warfarin to stay active in your system, which might increase the risk of side effects.
Warfarin carries more major-labeled pairs than Clomipramine
SPL source-record counts only. This page's band is minor · classes on file: Clomipramine (Tricyclic Antidepressant (TCA)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Clomipramine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 15 minor · 15 total
- Other minor peers for Clomipramine
- Sertraline
- Fluoxetine
- Methylphenidate
- Paroxetine
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.