Clomipramine and Methylphenidate Interaction
Drug interaction information between Clomipramine and Methylphenidate.
Clomipramine and Methylphenidate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clomipramine and Methylphenidate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Methylphenidate can interfere with how your body gets rid of clomipramine. This causes the amount of clomipramine in your system to increase.
FDA Label Information
The plasma concentration of CMI has been reported to be increased by the concomitant administration of haloperidol; plasma levels of several closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of methylphenidate or hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decreased by the concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and such an effect may be anticipated with CMI as well.
Clomipramine Also Interacts With
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Clonidine minor
- Warfarin minor
Methylphenidate Also Interacts With
- Safinamide major
- Dexmethylphenidate moderate
- Risperidone moderate
- Linezolid minor
- Phenelzine minor
Frequently Asked Questions
What SPL severity band is on file for Clomipramine + Methylphenidate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clomipramine has 15 labeled pairs on file vs Methylphenidate's 11. In the minor band specifically: Clomipramine has 15 (also Sertraline, Fluoxetine, Paroxetine, Clonidine); Methylphenidate has 8 (also Linezolid, Phenelzine, Tranylcypromine, Selegiline).
What mechanism field is on file for Clomipramine and Methylphenidate?
Methylphenidate can interfere with how your body gets rid of clomipramine. This causes the amount of clomipramine in your system to increase.
Methylphenidate carries more major-labeled pairs than Clomipramine
SPL source-record counts only. This page's band is minor · classes on file: Clomipramine (Tricyclic Antidepressant (TCA)); Methylphenidate (CNS Stimulant).
Methylphenidate has 1 major-labeled pair vs Clomipramine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 15 minor · 15 total
- Other minor peers for Clomipramine
- Sertraline
- Fluoxetine
- Paroxetine
- Clonidine
1 major · 2 moderate · 8 minor · 11 total
- Other minor peers for Methylphenidate
- Linezolid
- Phenelzine
- Tranylcypromine
- Selegiline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.