Clomipramine and Methylphenidate Interaction
Drug interaction information between Clomipramine and Methylphenidate.
Clomipramine and Methylphenidate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clomipramine and Methylphenidate. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Methylphenidate can interfere with how your body gets rid of clomipramine. This causes the amount of clomipramine in your system to increase.
What To Do
Your doctor may need to change your clomipramine dose and check how you are feeling more often.
FDA Label Information
The plasma concentration of CMI has been reported to be increased by the concomitant administration of haloperidol; plasma levels of several closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of methylphenidate or hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decreased by the concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and such an effect may be anticipated with CMI as well.
Clomipramine Also Interacts With
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Clonidine minor
- Warfarin minor
Methylphenidate Also Interacts With
- Safinamide major
- Dexmethylphenidate moderate
- Risperidone moderate
- Linezolid minor
- Phenelzine minor
Frequently Asked Questions
Can I take Clomipramine and Methylphenidate together?
This is a minor interaction. Your doctor may need to change your clomipramine dose and check how you are feeling more often.
How serious is the interaction between Clomipramine and Methylphenidate?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Clomipramine and Methylphenidate interact?
Methylphenidate can interfere with how your body gets rid of clomipramine. This causes the amount of clomipramine in your system to increase.
Understanding the Clomipramine and Methylphenidate Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Clomipramine belongs to the Tricyclic Antidepressant (TCA) class and Methylphenidate belongs to the CNS Stimulant class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Methylphenidate can interfere with how your body gets rid of clomipramine. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Clomipramine has 15 total documented interactions on file in this dataset, and Methylphenidate has 11. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to change your clomipramine dose and check how you are feeling more often. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Clomipramine or Methylphenidate based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.