What the FDA labels say about taking them together
Clomipramine and methylphenidate
Clomipramine's FDA label of November 26, 2024 names methylphenidate in its drug interactions section; the methylphenidate labels PlainMeds reads (4) do not name clomipramine. The clomipramine label: “… antidepressants have been reported to be increased by the concomitant administration of methylphenidate or hepatic enzyme inhibitors and decreased by the concomitant administration of hepatic enzyme inducers, and such …”
Check it at the source: the clomipramine FDA label on DailyMed (effective November 26, 2024); the methylphenidate FDA label on DailyMed (effective July 31, 2026, Lannett Company, LLC).
What does the clomipramine label say about methylphenidate?
Clomipramine label, drug interactionsThe plasma concentration of CMI has been reported to be increased by the concomitant administration of haloperidol; plasma levels of several closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of methylphenidate or hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decreased by the concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and such an effect may be anticipated with CMI as well.
Source: FDA drug label (CLOMIPRAMINE HYDROCHLORIDE), SpecGx LLC, effective November 26, 2024 (SPL set d7cee3fa-d05c-4702-8f75-f446627bdb49), via openFDA; the full label on DailyMed
What does the methylphenidate label say about clomipramine?
Methylphenidate's label (effective July 31, 2026) and its 3 other brand-application labels do not name clomipramine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (methylphenidate hydrochloride CD), Lannett Company, LLC, effective July 31, 2026 (SPL set e45c75dc-d381-475b-b649-a871c8a36e60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clomipramine | Methylphenidate | |
|---|---|---|
| Labeled for | n/a | ADHD |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.189 per capsule 25 mg capsule | $0.158 per tablet 10 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once