What the FDA labels say about taking them together
Clomipramine and clonidine
Clomipramine's FDA label of November 26, 2024 names clonidine in its drug interactions section; clonidine's label does not name clomipramine itself but warns about its class (Tricyclic antidepressants).
Check it at the source: the clomipramine FDA label on DailyMed (effective November 26, 2024); the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.).
What does the clomipramine label say about clonidine?
Clomipramine label, drug interactionsSeveral tricyclic antidepressants have been reported to block the pharmacologic effects of guanethidine, clonidine, or similar agents, and such an effect may be anticipated with CMI because of its structural similarity to other tricyclic antidepressants.
Source: FDA drug label (CLOMIPRAMINE HYDROCHLORIDE), SpecGx LLC, effective November 26, 2024 (SPL set d7cee3fa-d05c-4702-8f75-f446627bdb49), via openFDA; the full label on DailyMed
What does the clonidine label say about clomipramine?
Clonidine's label does not name clomipramine itself; it warns about its class (Tricyclic antidepressants):
Clonidine label, drug interactionsIf a patient receiving clonidine hydrochloride is also taking tricyclic antidepressants, the hypotensive effect of clonidine may be reduced, necessitating an increase in the clonidine dose.
Clonidine label, drug interactionsTricyclic antidepressants Clinical Implication Concomitant use of tricyclic antidepressants with clonidine can increase blood pressure and may counteract the hypotensive effects of clonidine.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clomipramine | Clonidine | |
|---|---|---|
| Labeled for | n/a | High blood pressure, ADHD, Pain |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.189 per capsule 25 mg capsule | $0.0241 per tablet 0.1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once