Clomipramine and Clonidine Interaction
Drug interaction information between Clomipramine and Clonidine.
Clomipramine and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clomipramine and Clonidine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Clomipramine can interfere with how clonidine works in your body. This prevents clonidine from effectively lowering your blood pressure.
What To Do
Your doctor should check your blood pressure regularly to make sure your blood pressure medicine is still working.
FDA Label Information
Several tricyclic antidepressants have been reported to block the pharmacologic effects of guanethidine, clonidine, or similar agents, and such an effect may be anticipated with CMI because of its structural similarity to other tricyclic antidepressants.
Clomipramine Also Interacts With
- Sertraline minor
- Fluoxetine minor
- Methylphenidate minor
- Paroxetine minor
- Warfarin minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
Can I take Clomipramine and Clonidine together?
This is a minor interaction. Your doctor should check your blood pressure regularly to make sure your blood pressure medicine is still working.
How serious is the interaction between Clomipramine and Clonidine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Clomipramine and Clonidine interact?
Clomipramine can interfere with how clonidine works in your body. This prevents clonidine from effectively lowering your blood pressure.
Understanding the Clomipramine and Clonidine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Clomipramine belongs to the Tricyclic Antidepressant (TCA) class and Clonidine belongs to the Central Alpha-2 Agonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Clomipramine can interfere with how clonidine works in your body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Clomipramine has 15 total documented interactions on file in this dataset, and Clonidine has 29. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should check your blood pressure regularly to make sure your blood pressure medicine is still working. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Clomipramine or Clonidine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.