Clomipramine and Clonidine Interaction
Drug interaction information between Clomipramine and Clonidine.
Clomipramine and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clomipramine and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clomipramine can interfere with how clonidine works in your body. This prevents clonidine from effectively lowering your blood pressure.
FDA Label Information
Several tricyclic antidepressants have been reported to block the pharmacologic effects of guanethidine, clonidine, or similar agents, and such an effect may be anticipated with CMI because of its structural similarity to other tricyclic antidepressants.
Clomipramine Also Interacts With
- Sertraline minor
- Fluoxetine minor
- Methylphenidate minor
- Paroxetine minor
- Warfarin minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Clomipramine + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Clomipramine's 15. In the minor band specifically: Clomipramine has 15 (also Sertraline, Fluoxetine, Methylphenidate, Paroxetine); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Clomipramine and Clonidine?
Clomipramine can interfere with how clonidine works in your body. This prevents clonidine from effectively lowering your blood pressure.
Clonidine's labeled portfolio outnumbers Clomipramine
SPL source-record counts only. This page's band is minor · classes on file: Clomipramine (Tricyclic Antidepressant (TCA)); Clonidine (Central Alpha-2 Agonist).
0 major · 0 moderate · 15 minor · 15 total
- Other minor peers for Clomipramine
- Sertraline
- Fluoxetine
- Methylphenidate
- Paroxetine
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.