Alosetron and Itraconazole Interaction
Drug interaction information between Alosetron and Itraconazole.
Alosetron and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Alosetron and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole may block the liver enzymes that break down alosetron, which could lead to higher levels of the drug in your body.
FDA Label Information
Coadministration of alosetron and strong CYP3A4 inhibitors such as clarithromycin, telithromycin, protease inhibitors, voriconazole, and itraconazole has not been evaluated but should be undertaken with caution because of similar potential drug interactions.
Alosetron Also Interacts With
- Clarithromycin moderate
- Voriconazole moderate
- Estradiol minor
- Hydralazine minor
- Ketoconazole minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Alosetron + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Alosetron's 12. In the moderate band specifically: Alosetron has 3 (also Clarithromycin, Voriconazole); Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Alosetron and Itraconazole?
Itraconazole may block the liver enzymes that break down alosetron, which could lead to higher levels of the drug in your body.
Itraconazole carries more major-labeled pairs than Alosetron
SPL source-record counts only. This page's band is moderate · classes on file: Alosetron (5-HT3 Antagonist (IBS-D)); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Alosetron's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 9 minor · 12 total
- Other moderate peers for Alosetron
- Clarithromycin
- Voriconazole
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.