Alosetron and Estradiol Interaction
Drug interaction information between Alosetron and Estradiol.
Alosetron and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alosetron and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Alosetron does not seem to change the amount of estradiol in your blood.
FDA Label Information
Another study showed that alosetron had no clinically significant effect on plasma concentrations of the oral contraceptive agents ethinyl estradiol and levonorgestrel (CYP3A4 substrates).
Alosetron Also Interacts With
- Clarithromycin moderate
- Itraconazole moderate
- Voriconazole moderate
- Hydralazine minor
- Ketoconazole minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Alosetron + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Alosetron's 12. In the minor band specifically: Alosetron has 9 (also Hydralazine, Ketoconazole, Theophylline, Cimetidine); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Alosetron and Estradiol?
Alosetron does not seem to change the amount of estradiol in your blood.
Estradiol carries more major-labeled pairs than Alosetron
SPL source-record counts only. This page's band is minor · classes on file: Alosetron (5-HT3 Antagonist (IBS-D)); Estradiol (Estrogen Hormone).
Estradiol has 1 major-labeled pair vs Alosetron's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 9 minor · 12 total
- Other minor peers for Alosetron
- Hydralazine
- Ketoconazole
- Theophylline
- Cimetidine
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.