Alosetron and Estradiol Interaction
Drug interaction information between Alosetron and Estradiol.
Alosetron and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alosetron and Estradiol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Alosetron does not seem to change the amount of estradiol in your blood.
What To Do
You can typically take these medications together without needing to change your dose.
FDA Label Information
Another study showed that alosetron had no clinically significant effect on plasma concentrations of the oral contraceptive agents ethinyl estradiol and levonorgestrel (CYP3A4 substrates).
Alosetron Also Interacts With
- Clarithromycin moderate
- Itraconazole moderate
- Voriconazole moderate
- Hydralazine minor
- Ketoconazole minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
Can I take Alosetron and Estradiol together?
This is a minor interaction. You can typically take these medications together without needing to change your dose.
How serious is the interaction between Alosetron and Estradiol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Alosetron and Estradiol interact?
Alosetron does not seem to change the amount of estradiol in your blood.
Understanding the Alosetron and Estradiol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Alosetron belongs to the 5-HT3 Antagonist (IBS-D) class and Estradiol belongs to the Estrogen Hormone class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Alosetron does not seem to change the amount of estradiol in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Alosetron has 12 total documented interactions on file in this dataset, and Estradiol has 54. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can typically take these medications together without needing to change your dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Alosetron or Estradiol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.