Alosetron and Voriconazole Interaction
Drug interaction information between Alosetron and Voriconazole.
Alosetron and Voriconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Alosetron and Voriconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Voriconazole can slow down how your body processes alosetron, potentially causing the medication to build up in your system.
What To Do
Be careful when taking these drugs together and report any unusual symptoms to your healthcare provider.
FDA Label Information
Coadministration of alosetron and strong CYP3A4 inhibitors such as clarithromycin, telithromycin, protease inhibitors, voriconazole, and itraconazole has not been evaluated but should be undertaken with caution because of similar potential drug interactions.
Alosetron Also Interacts With
- Clarithromycin moderate
- Itraconazole moderate
- Estradiol minor
- Hydralazine minor
- Ketoconazole minor
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Frequently Asked Questions
Can I take Alosetron and Voriconazole together?
This is a moderate interaction. Be careful when taking these drugs together and report any unusual symptoms to your healthcare provider.
How serious is the interaction between Alosetron and Voriconazole?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Alosetron and Voriconazole interact?
Voriconazole can slow down how your body processes alosetron, potentially causing the medication to build up in your system.
Understanding the Alosetron and Voriconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Alosetron belongs to the 5-HT3 Antagonist (IBS-D) class and Voriconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Voriconazole can slow down how your body processes alosetron, potentially causing the medication to build up in your system. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Alosetron has 12 total documented interactions on file in this dataset, and Voriconazole has 50. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Be careful when taking these drugs together and report any unusual symptoms to your healthcare provider. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Alosetron or Voriconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.