Alosetron and Hydralazine Interaction
Drug interaction information between Alosetron and Hydralazine.
Alosetron and Hydralazine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alosetron and Hydralazine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Alosetron may interfere with the way your body processes hydralazine, potentially leading to higher drug levels.
What To Do
Talk to your doctor about monitoring your blood pressure and watching for any new symptoms.
FDA Label Information
Although not studied with alosetron, inhibition of N-acetyltransferase may have clinically relevant consequences for drugs such as isoniazid, procainamide, and hydralazine.
Alosetron Also Interacts With
- Clarithromycin moderate
- Itraconazole moderate
- Voriconazole moderate
- Estradiol minor
- Ketoconazole minor
Frequently Asked Questions
Can I take Alosetron and Hydralazine together?
This is a minor interaction. Talk to your doctor about monitoring your blood pressure and watching for any new symptoms.
How serious is the interaction between Alosetron and Hydralazine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Alosetron and Hydralazine interact?
Alosetron may interfere with the way your body processes hydralazine, potentially leading to higher drug levels.
Understanding the Alosetron and Hydralazine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Alosetron belongs to the 5-HT3 Antagonist (IBS-D) class and Hydralazine belongs to the Vasodilator class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Alosetron may interfere with the way your body processes hydralazine, potentially leading to higher drug levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Alosetron has 12 total documented interactions on file in this dataset, and Hydralazine has 3. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Talk to your doctor about monitoring your blood pressure and watching for any new symptoms. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Alosetron or Hydralazine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.