Alosetron and Clarithromycin Interaction
Drug interaction information between Alosetron and Clarithromycin.
Alosetron and Clarithromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Alosetron and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin blocks the enzymes that break down alosetron, which could lead to higher levels of alosetron in your body.
FDA Label Information
Coadministration of alosetron and strong CYP3A4 inhibitors such as clarithromycin, telithromycin, protease inhibitors, voriconazole, and itraconazole has not been evaluated but should be undertaken with caution because of similar potential drug interactions.
Alosetron Also Interacts With
- Itraconazole moderate
- Voriconazole moderate
- Estradiol minor
- Hydralazine minor
- Ketoconazole minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Alosetron + Clarithromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Alosetron's 12. In the moderate band specifically: Alosetron has 3 (also Itraconazole, Voriconazole); Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate).
What mechanism field is on file for Alosetron and Clarithromycin?
Clarithromycin blocks the enzymes that break down alosetron, which could lead to higher levels of alosetron in your body.
Clarithromycin carries more major-labeled pairs than Alosetron
SPL source-record counts only. This page's band is moderate · classes on file: Alosetron (5-HT3 Antagonist (IBS-D)); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Alosetron's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 9 minor · 12 total
- Other moderate peers for Alosetron
- Itraconazole
- Voriconazole
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.