Alogliptin and Ranolazine Interaction
Drug interaction information between Alogliptin and Ranolazine.
Alogliptin and Ranolazine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alogliptin and Ranolazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranolazine can interfere with the body's ability to clear out metformin. This leads to higher levels of metformin in the body.
FDA Label Information
( 7 ) Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine), may increase the accumulation of metformin. Examples: Ranolazine, vandetanib, dolutegravir, and cimetidine Alcohol Clinical Impact: Alcohol is known to potentiate the effect of metformin on lactate metabolism.
Alogliptin Also Interacts With
- Topiramate moderate
- Zonisamide moderate
- Metformin minor
- Dolutegravir minor
- Cimetidine minor
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Frequently Asked Questions
What SPL severity band is on file for Alogliptin + Ranolazine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ranolazine has 31 labeled pairs on file vs Alogliptin's 7. In the minor band specifically: Alogliptin has 5 (also Metformin, Dolutegravir, Cimetidine, Phenytoin); Ranolazine has 12 (also Diltiazem, Fluconazole, Verapamil, Cyclosporine).
What mechanism field is on file for Alogliptin and Ranolazine?
Ranolazine can interfere with the body's ability to clear out metformin. This leads to higher levels of metformin in the body.
Ranolazine carries more major-labeled pairs than Alogliptin
SPL source-record counts only. This page's band is minor · classes on file: Alogliptin (DPP-4 Inhibitor); Ranolazine (Late Sodium Current Inhibitor (Antianginal)).
Ranolazine has 12 major-labeled pairs vs Alogliptin's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Alogliptin
- Metformin
- Dolutegravir
- Cimetidine
- Phenytoin
12 major · 7 moderate · 12 minor · 31 total
- Other minor peers for Ranolazine
- Diltiazem
- Fluconazole
- Verapamil
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.