Alogliptin and Zonisamide Interaction
Drug interaction information between Alogliptin and Zonisamide.
Alogliptin and Zonisamide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Alogliptin and Zonisamide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Zonisamide interferes with how your kidneys remove metformin from your body, which can increase the risk of a serious condition called lactic acidosis.
FDA Label Information
Examples: Topiramate, zonisamide, acetazolamide or dichlorphenamide Drugs that Reduce Metformin Clearance Clinical Impact: Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2]/multidrug and toxin extrusion [MATE] inhibitors) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology (12.3) ] .
Alogliptin Also Interacts With
- Topiramate moderate
- Metformin minor
- Dolutegravir minor
- Ranolazine minor
- Cimetidine minor
Zonisamide Also Interacts With
- Ertugliflozin moderate
- Topiramate moderate
- Carbamazepine minor
- Empagliflozin minor
- Empagliflozin/Linagliptin minor
Frequently Asked Questions
What SPL severity band is on file for Alogliptin + Zonisamide?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Zonisamide has 13 labeled pairs on file vs Alogliptin's 7. In the moderate band specifically: Alogliptin has 2 (also Topiramate); Zonisamide has 3 (also Ertugliflozin, Topiramate).
What mechanism field is on file for Alogliptin and Zonisamide?
Zonisamide interferes with how your kidneys remove metformin from your body, which can increase the risk of a serious condition called lactic acidosis.
Zonisamide's labeled portfolio outnumbers Alogliptin
SPL source-record counts only. This page's band is moderate · classes on file: Alogliptin (DPP-4 Inhibitor); Zonisamide (Anticonvulsant (Sulfonamide)).
0 major · 3 moderate · 10 minor · 13 total
- Other moderate peers for Zonisamide
- Ertugliflozin
- Topiramate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.