Alogliptin and Dolutegravir Interaction
Drug interaction information between Alogliptin and Dolutegravir.
Alogliptin and Dolutegravir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alogliptin and Dolutegravir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dolutegravir can slow down how quickly the body removes metformin. This can cause metformin to build up in the blood, increasing the risk of side effects.
FDA Label Information
( 7 ) Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine), may increase the accumulation of metformin. Examples: Ranolazine, vandetanib, dolutegravir, and cimetidine Alcohol Clinical Impact: Alcohol is known to potentiate the effect of metformin on lactate metabolism.
Alogliptin Also Interacts With
- Topiramate moderate
- Zonisamide moderate
- Metformin minor
- Ranolazine minor
- Cimetidine minor
Dolutegravir Also Interacts With
- Dofetilide major
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Frequently Asked Questions
What SPL severity band is on file for Alogliptin + Dolutegravir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dolutegravir has 28 labeled pairs on file vs Alogliptin's 7. In the minor band specifically: Alogliptin has 5 (also Metformin, Ranolazine, Cimetidine, Phenytoin); Dolutegravir has 21 (also Omeprazole, Prednisone, Estradiol, Carbamazepine).
What mechanism field is on file for Alogliptin and Dolutegravir?
Dolutegravir can slow down how quickly the body removes metformin. This can cause metformin to build up in the blood, increasing the risk of side effects.
Dolutegravir carries more major-labeled pairs than Alogliptin
SPL source-record counts only. This page's band is minor · classes on file: Alogliptin (DPP-4 Inhibitor); Dolutegravir (Integrase Strand Transfer Inhibitor).
Dolutegravir has 1 major-labeled pair vs Alogliptin's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Alogliptin
- Metformin
- Ranolazine
- Cimetidine
- Phenytoin
1 major · 6 moderate · 21 minor · 28 total
- Other minor peers for Dolutegravir
- Omeprazole
- Prednisone
- Estradiol
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.