Alogliptin and Phenytoin Interaction
Drug interaction information between Alogliptin and Phenytoin.
Alogliptin and Phenytoin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alogliptin and Phenytoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Phenytoin can affect blood sugar levels, which might change how well your diabetes medicine works.
FDA Label Information
Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs and isoniazid Alogliptin Cytochrome (CYP) P450, CYP-Substrates or Inhibitors Clinical Impact: Insulin Secretagogues and Insulin Insulin and insulin secretagogues are known to cause hypoglycemia.
Alogliptin Also Interacts With
- Topiramate moderate
- Zonisamide moderate
- Metformin minor
- Dolutegravir minor
- Ranolazine minor
Phenytoin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Posaconazole major
- Ranolazine major
- Voriconazole major
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Alogliptin + Phenytoin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenytoin has 147 labeled pairs on file vs Alogliptin's 7. In the minor band specifically: Alogliptin has 5 (also Metformin, Dolutegravir, Ranolazine, Cimetidine); Phenytoin has 120 (also Atorvastatin, Omeprazole, Simvastatin, Methylphenidate).
What mechanism field is on file for Alogliptin and Phenytoin?
Phenytoin can affect blood sugar levels, which might change how well your diabetes medicine works.
Phenytoin carries more major-labeled pairs than Alogliptin
SPL source-record counts only. This page's band is minor · classes on file: Alogliptin (DPP-4 Inhibitor); Phenytoin (Anticonvulsant (Hydantoin)).
Phenytoin has 4 major-labeled pairs vs Alogliptin's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Alogliptin
- Metformin
- Dolutegravir
- Ranolazine
- Cimetidine
4 major · 23 moderate · 120 minor · 147 total
- Other minor peers for Phenytoin
- Atorvastatin
- Omeprazole
- Simvastatin
- Methylphenidate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.