Alogliptin and Metformin Interaction
Drug interaction information between Alogliptin and Metformin.
Alogliptin and Metformin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alogliptin and Metformin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two drugs work in different ways to lower blood sugar. When taken together, they have an additive effect to help control blood sugar levels.
What To Do
Monitor your blood sugar levels regularly and follow your doctor's advice on managing your condition.
FDA Label Information
( 7 ) Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine), may increase the accumulation of metformin. ( 7 ) Alcohol can potentiate the effect of metformin on lactate metabolism. ( 7 ) Metformin HCl Carbonic Anhydrase Inhibitors Clinical Impact: Carbonic anhydrase inhibitors frequently cause a decrease in serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis.
Alogliptin Also Interacts With
- Topiramate moderate
- Zonisamide moderate
- Dolutegravir minor
- Ranolazine minor
- Cimetidine minor
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
Frequently Asked Questions
Can I take Alogliptin and Metformin together?
This is a minor interaction. Monitor your blood sugar levels regularly and follow your doctor's advice on managing your condition.
How serious is the interaction between Alogliptin and Metformin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Alogliptin and Metformin interact?
These two drugs work in different ways to lower blood sugar. When taken together, they have an additive effect to help control blood sugar levels.
Understanding the Alogliptin and Metformin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Alogliptin belongs to the DPP-4 Inhibitor class and Metformin belongs to the Biguanide class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two drugs work in different ways to lower blood sugar. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Alogliptin has 7 total documented interactions on file in this dataset, and Metformin has 27. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Monitor your blood sugar levels regularly and follow your doctor's advice on managing your condition. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Alogliptin or Metformin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.