Alogliptin and Metformin Interaction
Drug interaction information between Alogliptin and Metformin.
Alogliptin and Metformin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alogliptin and Metformin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs work in different ways to lower blood sugar. When taken together, they have an additive effect to help control blood sugar levels.
FDA Label Information
( 7 ) Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine), may increase the accumulation of metformin. ( 7 ) Alcohol can potentiate the effect of metformin on lactate metabolism. ( 7 ) Metformin HCl Carbonic Anhydrase Inhibitors Clinical Impact: Carbonic anhydrase inhibitors frequently cause a decrease in serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis.
Alogliptin Also Interacts With
- Topiramate moderate
- Zonisamide moderate
- Dolutegravir minor
- Ranolazine minor
- Cimetidine minor
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Alogliptin + Metformin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metformin has 27 labeled pairs on file vs Alogliptin's 7. In the minor band specifically: Alogliptin has 5 (also Dolutegravir, Ranolazine, Cimetidine, Phenytoin); Metformin has 17 (also Topiramate, Dolutegravir, Ranolazine, Cimetidine).
What mechanism field is on file for Alogliptin and Metformin?
These two drugs work in different ways to lower blood sugar. When taken together, they have an additive effect to help control blood sugar levels.
Metformin's labeled portfolio outnumbers Alogliptin
SPL source-record counts only. This page's band is minor · classes on file: Alogliptin (DPP-4 Inhibitor); Metformin (Biguanide).
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Alogliptin
- Dolutegravir
- Ranolazine
- Cimetidine
- Phenytoin
0 major · 10 moderate · 17 minor · 27 total
- Other minor peers for Metformin
- Topiramate
- Dolutegravir
- Ranolazine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.