Carbamazepine and Fluconazole Interaction
Drug interaction information between Carbamazepine and Fluconazole.
Carbamazepine and Fluconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Carbamazepine and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole slows down how fast your body gets rid of carbamazepine, which can lead to toxic levels of the drug in your blood.
FDA Label Information
Carbamazepine : Fluconazole inhibits the metabolism of carbamazepine and an increase in serum carbamazepine of 30% has been observed. There is a risk of developing carbamazepine toxicity. Dosage adjustment of carbamazepine may be necessary depending on concentration measurements/effect.
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Carbamazepine + Fluconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Fluconazole's 67. In the moderate band specifically: Carbamazepine has 16 (also Lithium, Apixaban, Desmopressin, Dronedarone); Fluconazole has 7 (also Atorvastatin, Simvastatin, Amiodarone, Fluvastatin).
What mechanism field is on file for Carbamazepine and Fluconazole?
Fluconazole slows down how fast your body gets rid of carbamazepine, which can lead to toxic levels of the drug in your blood.
Carbamazepine's labeled portfolio outnumbers Fluconazole
SPL source-record counts only. This page's band is moderate · classes on file: Carbamazepine (Anticonvulsant); Fluconazole (Azole Antifungal).
3 major · 16 moderate · 110 minor · 129 total
- Other moderate peers for Carbamazepine
- Lithium
- Apixaban
- Desmopressin
- Dronedarone
3 major · 7 moderate · 57 minor · 67 total
- Other moderate peers for Fluconazole
- Atorvastatin
- Simvastatin
- Amiodarone
- Fluvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.