Carbamazepine and Dronedarone Interaction
Drug interaction information between Carbamazepine and Dronedarone.
Carbamazepine and Dronedarone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Carbamazepine and Dronedarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine makes your body break down dronedarone much faster than it should, which can make the heart medicine stop working.
FDA Label Information
Rifampin and Other CYP3A Inducers Avoid rifampin or other CYP3A inducers such as phenobarbital, carbamazepine, phenytoin, and St.
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Dronedarone Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Voriconazole major
- Darunavir major
- Ezetimibe major
Frequently Asked Questions
What SPL severity band is on file for Carbamazepine + Dronedarone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Dronedarone's 22. In the moderate band specifically: Carbamazepine has 16 (also Lithium, Apixaban, Desmopressin, Fluconazole); Dronedarone has 5 (also Rifampin, Phenytoin, Phenobarbital, Lovastatin).
What mechanism field is on file for Carbamazepine and Dronedarone?
Carbamazepine makes your body break down dronedarone much faster than it should, which can make the heart medicine stop working.
Dronedarone carries more major-labeled pairs than Carbamazepine
SPL source-record counts only. This page's band is moderate · classes on file: Carbamazepine (Anticonvulsant); Dronedarone (Class III Antiarrhythmic).
Dronedarone has 9 major-labeled pairs vs Carbamazepine's 3. This page itself is in the moderate band, not the major band.
3 major · 16 moderate · 110 minor · 129 total
- Other moderate peers for Carbamazepine
- Lithium
- Apixaban
- Desmopressin
- Fluconazole
9 major · 5 moderate · 8 minor · 22 total
- Other moderate peers for Dronedarone
- Rifampin
- Phenytoin
- Phenobarbital
- Lovastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.