Dronedarone and Voriconazole Interaction
Drug interaction information between Dronedarone and Voriconazole.
Dronedarone and Voriconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Dronedarone and Voriconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole interferes with the way your body breaks down dronedarone. This results in much higher levels of dronedarone, which can be unsafe.
FDA Label Information
7.2 Effects of Other Drugs on Dronedarone Ketoconazole and Other Potent CYP3A Inhibitors Concomitant use of ketoconazole as well as other potent CYP3A inhibitors such as itraconazole, voriconazole, ritonavir, clarithromycin, and nefazodone is contraindicated because exposure to dronedarone is significantly increased [see Contraindications (4) , Clinical Pharmacology (12.3) ] .
Dronedarone Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Darunavir major
- Ezetimibe major
- Ezetimibe/Simvastatin major
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Frequently Asked Questions
What SPL severity band is on file for Dronedarone + Voriconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Dronedarone's 22. In the major band specifically: Dronedarone has 9 (also Ketoconazole, Clarithromycin, Darunavir, Ezetimibe); Voriconazole has 8 (also Norethindrone, Rifampin, Lurasidone, Pimozide).
What mechanism field is on file for Dronedarone and Voriconazole?
Voriconazole interferes with the way your body breaks down dronedarone. This results in much higher levels of dronedarone, which can be unsafe.
Dronedarone carries more major-labeled pairs than Voriconazole
SPL source-record counts only. This page's band is major · classes on file: Dronedarone (Class III Antiarrhythmic); Voriconazole (Azole Antifungal).
Dronedarone has 9 major-labeled pairs vs Voriconazole's 8.
9 major · 5 moderate · 8 minor · 22 total
- Other major peers for Dronedarone
- Ketoconazole
- Clarithromycin
- Darunavir
- Ezetimibe
8 major · 9 moderate · 33 minor · 50 total
- Other major peers for Voriconazole
- Norethindrone
- Rifampin
- Lurasidone
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.