Dronedarone and Phenobarbital Interaction
Drug interaction information between Dronedarone and Phenobarbital.
Dronedarone and Phenobarbital have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dronedarone and Phenobarbital. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Phenobarbital makes your body get rid of dronedarone too quickly, which can stop the medicine from working correctly.
FDA Label Information
Rifampin and Other CYP3A Inducers Avoid rifampin or other CYP3A inducers such as phenobarbital, carbamazepine, phenytoin, and St.
Dronedarone Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Voriconazole major
- Darunavir major
- Ezetimibe major
Phenobarbital Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Voriconazole major
- Canagliflozin moderate
- Cenobamate moderate
Frequently Asked Questions
What SPL severity band is on file for Dronedarone + Phenobarbital?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenobarbital has 59 labeled pairs on file vs Dronedarone's 22. In the moderate band specifically: Dronedarone has 5 (also Carbamazepine, Rifampin, Phenytoin, Lovastatin); Phenobarbital has 13 (also Canagliflozin, Cenobamate, Clarithromycin, Dapsone Topical).
What mechanism field is on file for Dronedarone and Phenobarbital?
Phenobarbital makes your body get rid of dronedarone too quickly, which can stop the medicine from working correctly.
Dronedarone carries more major-labeled pairs than Phenobarbital
SPL source-record counts only. This page's band is moderate · classes on file: Dronedarone (Class III Antiarrhythmic); Phenobarbital (Anticonvulsant (Barbiturate)).
Dronedarone has 9 major-labeled pairs vs Phenobarbital's 3. This page itself is in the moderate band, not the major band.
9 major · 5 moderate · 8 minor · 22 total
- Other moderate peers for Dronedarone
- Carbamazepine
- Rifampin
- Phenytoin
- Lovastatin
3 major · 13 moderate · 43 minor · 59 total
- Other moderate peers for Phenobarbital
- Canagliflozin
- Cenobamate
- Clarithromycin
- Dapsone Topical
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.