Dronedarone and Clarithromycin Interaction
Drug interaction information between Dronedarone and Clarithromycin.
Dronedarone and Clarithromycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Dronedarone and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin blocks the process your body uses to clear dronedarone. This leads to a significant increase in the amount of dronedarone in your blood.
FDA Label Information
7.2 Effects of Other Drugs on Dronedarone Ketoconazole and Other Potent CYP3A Inhibitors Concomitant use of ketoconazole as well as other potent CYP3A inhibitors such as itraconazole, voriconazole, ritonavir, clarithromycin, and nefazodone is contraindicated because exposure to dronedarone is significantly increased [see Contraindications (4) , Clinical Pharmacology (12.3) ] .
Dronedarone Also Interacts With
- Ketoconazole major
- Voriconazole major
- Darunavir major
- Ezetimibe major
- Ezetimibe/Simvastatin major
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Dronedarone + Clarithromycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Dronedarone's 22. In the major band specifically: Dronedarone has 9 (also Ketoconazole, Voriconazole, Darunavir, Ezetimibe); Clarithromycin has 16 (also Quetiapine, Pioglitazone, Fluconazole, Cyclosporine).
What mechanism field is on file for Dronedarone and Clarithromycin?
Clarithromycin blocks the process your body uses to clear dronedarone. This leads to a significant increase in the amount of dronedarone in your blood.
Clarithromycin carries more major-labeled pairs than Dronedarone
SPL source-record counts only. This page's band is major · classes on file: Dronedarone (Class III Antiarrhythmic); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Dronedarone's 9.
9 major · 5 moderate · 8 minor · 22 total
- Other major peers for Dronedarone
- Ketoconazole
- Voriconazole
- Darunavir
- Ezetimibe
16 major · 35 moderate · 30 minor · 81 total
- Other major peers for Clarithromycin
- Quetiapine
- Pioglitazone
- Fluconazole
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.