Dronedarone and Darunavir Interaction
Drug interaction information between Dronedarone and Darunavir.
Dronedarone and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Dronedarone and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir raises the level of dronedarone in your blood by slowing its breakdown. This can cause your heart to beat in a dangerous or irregular way.
FDA Label Information
dronedarone ↑ dronedarone Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as cardiac arrhythmias.
Dronedarone Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Voriconazole major
- Ezetimibe major
- Ezetimibe/Simvastatin major
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Dronedarone + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Dronedarone's 22. In the major band specifically: Dronedarone has 9 (also Ketoconazole, Clarithromycin, Voriconazole, Ezetimibe); Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide).
What mechanism field is on file for Dronedarone and Darunavir?
Darunavir raises the level of dronedarone in your blood by slowing its breakdown. This can cause your heart to beat in a dangerous or irregular way.
Darunavir carries more major-labeled pairs than Dronedarone
SPL source-record counts only. This page's band is major · classes on file: Dronedarone (Class III Antiarrhythmic); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Dronedarone's 9.
9 major · 5 moderate · 8 minor · 22 total
- Other major peers for Dronedarone
- Ketoconazole
- Clarithromycin
- Voriconazole
- Ezetimibe
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.