Dronedarone and Rifampin Interaction
Drug interaction information between Dronedarone and Rifampin.
Dronedarone and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dronedarone and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the liver's ability to process dronedarone, which lowers the amount of medicine in your blood to levels that are too low.
FDA Label Information
Rifampin and Other CYP3A Inducers Avoid rifampin or other CYP3A inducers such as phenobarbital, carbamazepine, phenytoin, and St.
Dronedarone Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Voriconazole major
- Darunavir major
- Ezetimibe major
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Dronedarone + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Dronedarone's 22. In the moderate band specifically: Dronedarone has 5 (also Carbamazepine, Phenytoin, Phenobarbital, Lovastatin); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Dronedarone and Rifampin?
Rifampin speeds up the liver's ability to process dronedarone, which lowers the amount of medicine in your blood to levels that are too low.
Dronedarone carries more major-labeled pairs than Rifampin
SPL source-record counts only. This page's band is moderate · classes on file: Dronedarone (Class III Antiarrhythmic); Rifampin (Rifamycin Antibiotic).
Dronedarone has 9 major-labeled pairs vs Rifampin's 8. This page itself is in the moderate band, not the major band.
9 major · 5 moderate · 8 minor · 22 total
- Other moderate peers for Dronedarone
- Carbamazepine
- Phenytoin
- Phenobarbital
- Lovastatin
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.