Dronedarone and Lovastatin Interaction
Drug interaction information between Dronedarone and Lovastatin.
Dronedarone and Lovastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dronedarone and Lovastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dronedarone slows down the removal of lovastatin from your system, especially when lovastatin is taken at higher doses. This can lead to toxic levels of the drug that harm your muscle tissue.
FDA Label Information
Danazol, Diltiazem, Dronedarone or Verapamil The risk of myopathy/rhabdomyolysis is increased by concomitant administration of danazol, diltiazem, dronedarone or verapamil particularly with higher doses of lovastatin (see WARNINGS , Myopathy/Rhabdomyolysis ; CLINICAL PHARMACOLOGY , Pharmacokinetics ).
Dronedarone Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Voriconazole major
- Darunavir major
- Ezetimibe major
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Dronedarone + Lovastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lovastatin has 30 labeled pairs on file vs Dronedarone's 22. In the moderate band specifically: Dronedarone has 5 (also Carbamazepine, Rifampin, Phenytoin, Phenobarbital); Lovastatin has 17 (also Spironolactone, Ketoconazole, Verapamil, Cyclosporine).
What mechanism field is on file for Dronedarone and Lovastatin?
Dronedarone slows down the removal of lovastatin from your system, especially when lovastatin is taken at higher doses. This can lead to toxic levels of the drug that harm your muscle tissue.
Dronedarone carries more major-labeled pairs than Lovastatin
SPL source-record counts only. This page's band is moderate · classes on file: Dronedarone (Class III Antiarrhythmic); Lovastatin (HMG-CoA Reductase Inhibitor (Statin)).
Dronedarone has 9 major-labeled pairs vs Lovastatin's 2. This page itself is in the moderate band, not the major band.
9 major · 5 moderate · 8 minor · 22 total
- Other moderate peers for Dronedarone
- Carbamazepine
- Rifampin
- Phenytoin
- Phenobarbital
2 major · 17 moderate · 11 minor · 30 total
- Other moderate peers for Lovastatin
- Spironolactone
- Ketoconazole
- Verapamil
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.