Bromocriptine and Pimozide Interaction
Drug interaction information between Bromocriptine and Pimozide.
Bromocriptine and Pimozide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bromocriptine and Pimozide. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Pimozide works against bromocriptine in the body. This makes the bromocriptine less effective at treating your condition.
What To Do
Your doctor may need to adjust your treatment because this combination can stop your medicine from working as well as it should.
FDA Label Information
Compounds in these categories result in a decreased efficacy of bromocriptine mesylate: phenothiazines, haloperidol, metoclopramide, and pimozide.
Bromocriptine Also Interacts With
- Clarithromycin moderate
- Erythromycin minor
- Haloperidol minor
- Dopamine minor
- Metoclopramide minor
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Frequently Asked Questions
Can I take Bromocriptine and Pimozide together?
This is a minor interaction. Your doctor may need to adjust your treatment because this combination can stop your medicine from working as well as it should.
How serious is the interaction between Bromocriptine and Pimozide?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Bromocriptine and Pimozide interact?
Pimozide works against bromocriptine in the body. This makes the bromocriptine less effective at treating your condition.
Understanding the Bromocriptine and Pimozide Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Bromocriptine belongs to the Dopamine Agonist (Diabetes) class and Pimozide belongs to the Typical Antipsychotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Pimozide works against bromocriptine in the body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Bromocriptine has 7 total documented interactions on file in this dataset, and Pimozide has 24. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to adjust your treatment because this combination can stop your medicine from working as well as it should. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Bromocriptine or Pimozide based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.