Pimozide and Darunavir Interaction
Drug interaction information between Pimozide and Darunavir.
Pimozide and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Pimozide and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir increases the level of pimozide in the body, which can cause the heart to beat in a dangerous way.
FDA Label Information
pimozide ↑ pimozide Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as cardiac arrhythmias.
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Escitalopram major
- Fluconazole major
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Midazolam major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Pimozide + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Pimozide's 24. In the major band specifically: Pimozide has 12 (also Aprepitant, Citalopram, Clarithromycin, Escitalopram); Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Midazolam).
What mechanism field is on file for Pimozide and Darunavir?
Darunavir increases the level of pimozide in the body, which can cause the heart to beat in a dangerous way.
Darunavir carries more major-labeled pairs than Pimozide
SPL source-record counts only. This page's band is major · classes on file: Pimozide (Typical Antipsychotic); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Pimozide's 12.
12 major · 0 moderate · 12 minor · 24 total
- Other major peers for Pimozide
- Aprepitant
- Citalopram
- Clarithromycin
- Escitalopram
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Midazolam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.