Pimozide and Chlorpromazine Interaction
Drug interaction information between Pimozide and Chlorpromazine.
Pimozide and Chlorpromazine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pimozide and Chlorpromazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs have the same side effect on the heart's electrical timing. Combining them makes it more likely you will experience a life-threatening irregular heartbeat.
FDA Label Information
Accordingly, pimozide should not be given with dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol, tacrolimus, ziprasidone, or other drugs that have demonstrated QT prolongation as one of their pharmacodynamic effects.
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Chlorpromazine Also Interacts With
- Desmopressin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
- Zolpidem moderate
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Pimozide + Chlorpromazine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pimozide has 24 labeled pairs on file vs Chlorpromazine's 11. In the minor band specifically: Pimozide has 12 (also Moxifloxacin, Ziprasidone, Thioridazine, Sotalol); Chlorpromazine has 7 (also Carbamazepine, Clozapine, Fluoxetine, Meperidine).
What mechanism field is on file for Pimozide and Chlorpromazine?
Both drugs have the same side effect on the heart's electrical timing. Combining them makes it more likely you will experience a life-threatening irregular heartbeat.
Pimozide carries more major-labeled pairs than Chlorpromazine
SPL source-record counts only. This page's band is minor · classes on file: Pimozide (Typical Antipsychotic); Chlorpromazine (Typical Antipsychotic (Phenothiazine)).
Pimozide has 12 major-labeled pairs vs Chlorpromazine's 0. This page itself is in the minor band, not the major band.
12 major · 0 moderate · 12 minor · 24 total
- Other minor peers for Pimozide
- Moxifloxacin
- Ziprasidone
- Thioridazine
- Sotalol
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Chlorpromazine
- Carbamazepine
- Clozapine
- Fluoxetine
- Meperidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.