Pimozide and Moxifloxacin Interaction
Drug interaction information between Pimozide and Moxifloxacin.
Pimozide and Moxifloxacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pimozide and Moxifloxacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause a change in the heart's electrical rhythm. Taking them together increases the risk of a dangerous heartbeat.
FDA Label Information
Accordingly, pimozide should not be given with dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol, tacrolimus, ziprasidone, or other drugs that have demonstrated QT prolongation as one of their pharmacodynamic effects.
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Moxifloxacin Also Interacts With
- Lefamulin moderate
- Warfarin minor
- Sotalol minor
- Sucralfate minor
- Zinc Sulfate minor
Frequently Asked Questions
What SPL severity band is on file for Pimozide + Moxifloxacin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pimozide has 24 labeled pairs on file vs Moxifloxacin's 10. In the minor band specifically: Pimozide has 12 (also Ziprasidone, Chlorpromazine, Thioridazine, Sotalol); Moxifloxacin has 9 (also Warfarin, Sotalol, Sucralfate, Zinc Sulfate).
What mechanism field is on file for Pimozide and Moxifloxacin?
Both drugs can cause a change in the heart's electrical rhythm. Taking them together increases the risk of a dangerous heartbeat.
Pimozide carries more major-labeled pairs than Moxifloxacin
SPL source-record counts only. This page's band is minor · classes on file: Pimozide (Typical Antipsychotic); Moxifloxacin (Fluoroquinolone Antibiotic).
Pimozide has 12 major-labeled pairs vs Moxifloxacin's 0. This page itself is in the minor band, not the major band.
12 major · 0 moderate · 12 minor · 24 total
- Other minor peers for Pimozide
- Ziprasidone
- Chlorpromazine
- Thioridazine
- Sotalol
0 major · 1 moderate · 9 minor · 10 total
- Other minor peers for Moxifloxacin
- Warfarin
- Sotalol
- Sucralfate
- Zinc Sulfate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.