Pimozide and Citalopram Interaction
Drug interaction information between Pimozide and Citalopram.
Pimozide and Citalopram have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Pimozide and Citalopram. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Citalopram increases the amount of pimozide in your blood, which can lead to dangerous heart rhythm problems.
FDA Label Information
Pimozide Clinical Impact: Concomitant use of citalopram with pimozide increases plasma concentrations of pimozide, a drug with a narrow therapeutic index, and may increase the risk of QT prolongation and/or ventricular arrhythmias compared to use of citalopram alone [see Clinical Pharmacology (12.2) ]. Intervention: Citalopram is contraindicated in patients taking pimozide [see Contraindications (4) , Warnings and Precautions (5.2) ]. Intervention: Avoid concomitant use of citalopram with drugs that prolong the QT interval (citalopram is contraindicated in patients taking pimozide) [see...
Pimozide Also Interacts With
- Aprepitant major
- Clarithromycin major
- Darunavir major
- Escitalopram major
- Fluconazole major
Citalopram Also Interacts With
- Linezolid major
- Escitalopram major
- Warfarin moderate
- Phenelzine moderate
- Buspirone minor
Frequently Asked Questions
What SPL severity band is on file for Pimozide + Citalopram?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pimozide has 24 labeled pairs on file vs Citalopram's 9. In the major band specifically: Pimozide has 12 (also Aprepitant, Clarithromycin, Darunavir, Escitalopram); Citalopram has 3 (also Linezolid, Escitalopram).
What mechanism field is on file for Pimozide and Citalopram?
Citalopram increases the amount of pimozide in your blood, which can lead to dangerous heart rhythm problems.
Pimozide carries more major-labeled pairs than Citalopram
SPL source-record counts only. This page's band is major · classes on file: Pimozide (Typical Antipsychotic); Citalopram (Selective Serotonin Reuptake Inhibitor (SSRI)).
Pimozide has 12 major-labeled pairs vs Citalopram's 3.
12 major · 0 moderate · 12 minor · 24 total
- Other major peers for Pimozide
- Aprepitant
- Clarithromycin
- Darunavir
- Escitalopram
3 major · 2 moderate · 4 minor · 9 total
- Other major peers for Citalopram
- Linezolid
- Escitalopram
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.