Pimozide and Clarithromycin Interaction
Drug interaction information between Pimozide and Clarithromycin.
Pimozide and Clarithromycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Pimozide and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin prevents the breakdown of pimozide, which can cause the drug to reach dangerous levels and potentially affect your heart rhythm.
FDA Label Information
Colchicine (in patients with normal renal and hepatic function) Use With Caution Antipsychotics: Pimozide Contraindicated Pimozide: [See Contraindications ( 4.2 )] Quetiapine Lurasidone Quetiapine: Quetiapine is a substrate for CYP3A4, which is inhibited by clarithromycin.
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Darunavir major
- Escitalopram major
- Fluconazole major
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Pimozide + Clarithromycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Pimozide's 24. In the major band specifically: Pimozide has 12 (also Aprepitant, Citalopram, Darunavir, Escitalopram); Clarithromycin has 16 (also Quetiapine, Pioglitazone, Fluconazole, Cyclosporine).
What mechanism field is on file for Pimozide and Clarithromycin?
Clarithromycin prevents the breakdown of pimozide, which can cause the drug to reach dangerous levels and potentially affect your heart rhythm.
Clarithromycin carries more major-labeled pairs than Pimozide
SPL source-record counts only. This page's band is major · classes on file: Pimozide (Typical Antipsychotic); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Pimozide's 12.
12 major · 0 moderate · 12 minor · 24 total
- Other major peers for Pimozide
- Aprepitant
- Citalopram
- Darunavir
- Escitalopram
16 major · 35 moderate · 30 minor · 81 total
- Other major peers for Clarithromycin
- Quetiapine
- Pioglitazone
- Fluconazole
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.