Pimozide and Aprepitant Interaction
Drug interaction information between Pimozide and Aprepitant.
Pimozide and Aprepitant have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Pimozide and Aprepitant. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aprepitant stops the body from breaking down pimozide, which can cause pimozide to build up to dangerous levels in the blood.
Pimozide Also Interacts With
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
- Fluconazole major
Aprepitant Also Interacts With
- Alprazolam moderate
- Diltiazem moderate
- Methylprednisolone moderate
- Ketoconazole moderate
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Pimozide + Aprepitant?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pimozide has 24 labeled pairs on file vs Aprepitant's 22. In the major band specifically: Pimozide has 12 (also Citalopram, Clarithromycin, Darunavir, Escitalopram); Aprepitant has 1.
What mechanism field is on file for Pimozide and Aprepitant?
Aprepitant stops the body from breaking down pimozide, which can cause pimozide to build up to dangerous levels in the blood.
Pimozide carries more major-labeled pairs than Aprepitant
SPL source-record counts only. This page's band is major · classes on file: Pimozide (Typical Antipsychotic); Aprepitant (NK1 Receptor Antagonist (Antiemetic)).
Pimozide has 12 major-labeled pairs vs Aprepitant's 1.
12 major · 0 moderate · 12 minor · 24 total
- Other major peers for Pimozide
- Citalopram
- Clarithromycin
- Darunavir
- Escitalopram
1 major · 9 moderate · 12 minor · 22 total
Aprepitant has no other major-band peer in this dataset besides Pimozide.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.