Pimozide and Escitalopram Interaction
Drug interaction information between Pimozide and Escitalopram.
Pimozide and Escitalopram have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Pimozide and Escitalopram. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Escitalopram raises the amount of pimozide in your blood, which can cause dangerous heart rhythm issues.
FDA Label Information
Intervention: Escitalopram is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [ see Dosage and Administration (2.7) , Contraindications (4) , and Warnings and Precautions (5.2) ] Pimozide Clinical Impact: Concomitant use of racemic citalopram with pimozide increases plasma concentrations of pimozide, a drug with a narrow therapeutic index, and may increase the risk of QT prolongation and/or ventricular arrhythmias compared to use of racemic citalopram alone [ see Clinical Pharmacology (12.3) ]. Intervention: Escitalopram is...
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Fluconazole major
Escitalopram Also Interacts With
- Citalopram major
- Linezolid major
- Aspirin moderate
- Warfarin moderate
- Buspirone minor
Frequently Asked Questions
What SPL severity band is on file for Pimozide + Escitalopram?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pimozide has 24 labeled pairs on file vs Escitalopram's 12. In the major band specifically: Pimozide has 12 (also Aprepitant, Citalopram, Clarithromycin, Darunavir); Escitalopram has 3 (also Citalopram, Linezolid).
What mechanism field is on file for Pimozide and Escitalopram?
Escitalopram raises the amount of pimozide in your blood, which can cause dangerous heart rhythm issues.
Pimozide carries more major-labeled pairs than Escitalopram
SPL source-record counts only. This page's band is major · classes on file: Pimozide (Typical Antipsychotic); Escitalopram (Selective Serotonin Reuptake Inhibitor (SSRI)).
Pimozide has 12 major-labeled pairs vs Escitalopram's 3.
12 major · 0 moderate · 12 minor · 24 total
- Other major peers for Pimozide
- Aprepitant
- Citalopram
- Clarithromycin
- Darunavir
3 major · 2 moderate · 7 minor · 12 total
- Other major peers for Escitalopram
- Citalopram
- Linezolid
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.