Bromocriptine and Metoclopramide Interaction
Drug interaction information between Bromocriptine and Metoclopramide.
Bromocriptine and Metoclopramide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bromocriptine and Metoclopramide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoclopramide blocks the same spots in the brain that bromocriptine needs to reach. This prevents the bromocriptine from working as well as it should.
FDA Label Information
Compounds in these categories result in a decreased efficacy of bromocriptine mesylate: phenothiazines, haloperidol, metoclopramide, and pimozide.
Bromocriptine Also Interacts With
- Clarithromycin moderate
- Erythromycin minor
- Pimozide minor
- Haloperidol minor
- Dopamine minor
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Bromocriptine + Metoclopramide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metoclopramide has 23 labeled pairs on file vs Bromocriptine's 7. In the minor band specifically: Bromocriptine has 6 (also Erythromycin, Pimozide, Haloperidol, Dopamine); Metoclopramide has 18 (also Acetaminophen, Cyclosporine, Tetracycline, Atovaquone/Proguanil).
What mechanism field is on file for Bromocriptine and Metoclopramide?
Metoclopramide blocks the same spots in the brain that bromocriptine needs to reach. This prevents the bromocriptine from working as well as it should.
Metoclopramide carries more major-labeled pairs than Bromocriptine
SPL source-record counts only. This page's band is minor · classes on file: Bromocriptine (Dopamine Agonist (Diabetes)); Metoclopramide (Prokinetic / Antiemetic).
Metoclopramide has 1 major-labeled pair vs Bromocriptine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 6 minor · 7 total
- Other minor peers for Bromocriptine
- Erythromycin
- Pimozide
- Haloperidol
- Dopamine
1 major · 4 moderate · 18 minor · 23 total
- Other minor peers for Metoclopramide
- Acetaminophen
- Cyclosporine
- Tetracycline
- Atovaquone/Proguanil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.