Pimozide and Ziprasidone Interaction
Drug interaction information between Pimozide and Ziprasidone.
Pimozide and Ziprasidone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pimozide and Ziprasidone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines both affect how the heart's electrical system resets after each beat. Using them together can lead to serious heart rhythm problems.
FDA Label Information
Accordingly, pimozide should not be given with dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol, tacrolimus, ziprasidone, or other drugs that have demonstrated QT prolongation as one of their pharmacodynamic effects.
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Ziprasidone Also Interacts With
- Buspirone moderate
- Lithium moderate
- Tetrabenazine moderate
- Estradiol minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Pimozide + Ziprasidone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pimozide has 24 labeled pairs on file vs Ziprasidone's 18. In the minor band specifically: Pimozide has 12 (also Moxifloxacin, Chlorpromazine, Thioridazine, Sotalol); Ziprasidone has 15 (also Estradiol, Propranolol, Lorazepam, Progesterone).
What mechanism field is on file for Pimozide and Ziprasidone?
These medicines both affect how the heart's electrical system resets after each beat. Using them together can lead to serious heart rhythm problems.
Pimozide carries more major-labeled pairs than Ziprasidone
SPL source-record counts only. This page's band is minor · classes on file: Pimozide (Typical Antipsychotic); Ziprasidone (Atypical Antipsychotic).
Pimozide has 12 major-labeled pairs vs Ziprasidone's 0. This page itself is in the minor band, not the major band.
12 major · 0 moderate · 12 minor · 24 total
- Other minor peers for Pimozide
- Moxifloxacin
- Chlorpromazine
- Thioridazine
- Sotalol
0 major · 3 moderate · 15 minor · 18 total
- Other minor peers for Ziprasidone
- Estradiol
- Propranolol
- Lorazepam
- Progesterone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.