Atorvastatin and Fluconazole Interaction
Drug interaction information between Atorvastatin and Fluconazole.
Atorvastatin and Fluconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Atorvastatin and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole changes how your body processes atorvastatin, which can lead to a dangerous buildup and cause muscle damage.
FDA Label Information
HMG-CoA reductase inhibitors : The risk of myopathy and rhabdomyolysis increases when fluconazole is coadministered with HMG-CoA reductase inhibitors metabolized through CYP3A4, such as atorvastatin and simvastatin, or through CYP2C9, such as fluvastatin.
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Simvastatin moderate
- Carbamazepine moderate
Frequently Asked Questions
What SPL severity band is on file for Atorvastatin + Fluconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Atorvastatin's 36. In the moderate band specifically: Atorvastatin has 8 (also Cyclosporine, Colchicine, Gemfibrozil, Niacin); Fluconazole has 7 (also Simvastatin, Carbamazepine, Amiodarone, Fluvastatin).
What mechanism field is on file for Atorvastatin and Fluconazole?
Fluconazole changes how your body processes atorvastatin, which can lead to a dangerous buildup and cause muscle damage.
Fluconazole's labeled portfolio outnumbers Atorvastatin
SPL source-record counts only. This page's band is moderate · classes on file: Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)); Fluconazole (Azole Antifungal).
3 major · 8 moderate · 25 minor · 36 total
- Other moderate peers for Atorvastatin
- Cyclosporine
- Colchicine
- Gemfibrozil
- Niacin
3 major · 7 moderate · 57 minor · 67 total
- Other moderate peers for Fluconazole
- Simvastatin
- Carbamazepine
- Amiodarone
- Fluvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.