Atorvastatin and Gemfibrozil Interaction
Drug interaction information between Atorvastatin and Gemfibrozil.
Atorvastatin and Gemfibrozil have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Atorvastatin and Gemfibrozil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause muscle injury on their own, and using them at the same time significantly increases the risk of severe muscle breakdown.
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Eluxadoline moderate
Frequently Asked Questions
What SPL severity band is on file for Atorvastatin + Gemfibrozil?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Gemfibrozil's 20. In the moderate band specifically: Atorvastatin has 8 (also Cyclosporine, Colchicine, Niacin, Fluconazole); Gemfibrozil has 8 (also Eluxadoline, Fluvastatin, Lovastatin, Pitavastatin).
What mechanism field is on file for Atorvastatin and Gemfibrozil?
Both drugs can cause muscle injury on their own, and using them at the same time significantly increases the risk of severe muscle breakdown.
Gemfibrozil carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is moderate · classes on file: Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)); Gemfibrozil (Fibrate).
Gemfibrozil has 4 major-labeled pairs vs Atorvastatin's 3. This page itself is in the moderate band, not the major band.
3 major · 8 moderate · 25 minor · 36 total
- Other moderate peers for Atorvastatin
- Cyclosporine
- Colchicine
- Niacin
- Fluconazole
4 major · 8 moderate · 8 minor · 20 total
- Other moderate peers for Gemfibrozil
- Eluxadoline
- Fluvastatin
- Lovastatin
- Pitavastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.