atorvastatin vs fluconazole
Side-by-side comparison of atorvastatin and fluconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
HMG-CoA reductase inhibitors : The risk of myopathy and rhabdomyolysis increases when fluconazole is coadministered with HMG-CoA reductase inhibitors metabolized through CYP3A4, such as atorvastatin and simvastatin, or through CYP2C9, such as fluvastatin.
Recommendation: Your doctor may need to adjust your dosage or monitor you closely for muscle pain and weakness.
Lipitor
Diflucan
Atorvastatin is a drug that lowers cholesterol and reduces the risk of heart problems and stroke. It belongs to a class of drugs called statins.
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Atorvastatin is used to lower bad cholesterol (LDL) and triglycerides in your blood. It can help prevent heart attacks, strokes, and the need for heart procedures in adults with heart disease or risk factors for it. It is also used in children 10 years and older with certain inherited cholesterol problems.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Atorvastatin works by blocking a substance your body needs to make cholesterol. This helps to lower the amount of cholesterol in your blood. Lowering cholesterol can help prevent heart disease.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
- • Common cold symptoms
- • Joint pain
- • Diarrhea
- • Pain in arms or legs
- • Urinary tract infection
- • Headache
- • Nausea
- • Abdominal pain
- Tiredness 13,809
- Feeling sick to your stomach 12,421
- Type 2 diabetes 11,243
- Diarrhea 11,034
- Difficulty breathing 11,029
- Fever 4,121
- Feeling sick to your stomach 3,695
- Loose stools 3,536
- Feeling tired 3,152
- Discomfort 3,121
Atorvastatin can cause muscle problems, including muscle pain, tenderness, or weakness. In rare cases, this can lead to serious kidney damage. Tell your doctor right away if you have unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or feel sick. Atorvastatin can also cause liver problems. Your doctor may do blood tests to check your liver before you start taking atorvastatin and while you are taking it.
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
Atorvastatin can harm an unborn baby. You should not take atorvastatin if you are pregnant or planning to become pregnant. It is also not recommended to breastfeed while taking atorvastatin.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
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How to Read This atorvastatin vs fluconazole Comparison
atorvastatin is classified in the HMG-CoA Reductase Inhibitor (Statin) drug class, while fluconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, atorvastatin has 59,536 submissions while fluconazole has 17,625. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to fluconazole changes how your body processes atorvastatin, which can lead to a dangerous buildup and cause muscle damage.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between atorvastatin and fluconazole - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.