Lithium and Celecoxib Interaction
Drug interaction information between Lithium and Celecoxib.
Lithium and Celecoxib have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lithium and Celecoxib. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Celecoxib makes it harder for the kidneys to remove lithium from the body, which can cause lithium levels to rise in the blood.
FDA Label Information
Lithium Clinical Impact: NSAIDs have produced elevations in plasma lithium levels and reductions in renal lithium clearance . The mean minimum lithium concentration increased 15%, and the renal clearance decreased by approximately 20%. Intervention: During concomitant use of celecoxib and lithium, monitor patients for signs of lithium toxicity.
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Celecoxib Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Meloxicam minor
- Furosemide minor
Frequently Asked Questions
What SPL severity band is on file for Lithium + Celecoxib?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Celecoxib's 19. In the minor band specifically: Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan); Celecoxib has 16 (also Meloxicam, Furosemide, Aspirin, Propranolol).
What mechanism field is on file for Lithium and Celecoxib?
Celecoxib makes it harder for the kidneys to remove lithium from the body, which can cause lithium levels to rise in the blood.
Lithium carries more major-labeled pairs than Celecoxib
SPL source-record counts only. This page's band is minor · classes on file: Lithium (Mood Stabilizer); Celecoxib (COX-2 Selective NSAID).
Lithium has 2 major-labeled pairs vs Celecoxib's 0. This page itself is in the minor band, not the major band.
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
0 major · 3 moderate · 16 minor · 19 total
- Other minor peers for Celecoxib
- Meloxicam
- Furosemide
- Aspirin
- Propranolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.