Lithium and Amlodipine/Valsartan Interaction
Drug interaction information between Lithium and Amlodipine/Valsartan.
Lithium and Amlodipine/Valsartan have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lithium and Amlodipine/Valsartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Valsartan can make it harder for your kidneys to clear lithium from your body. This can cause lithium to build up to levels that are poisonous to your system.
FDA Label Information
Valsartan – Hydrochlorothiazide Lithium: Increases in serum lithium concentrations and lithium toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists or thiazides. Monitor lithium levels in patients taking Exforge HCT. ( 12.3 ) Lithium: Increased risk of lithium toxicity.
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Azilsartan moderate
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Aliskiren major
- Cyclosporine moderate
- Amlodipine minor
- Hydrochlorothiazide minor
Frequently Asked Questions
What SPL severity band is on file for Lithium + Amlodipine/Valsartan?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Amlodipine/Valsartan's 14. In the moderate band specifically: Lithium has 23 (also Amiloride, Amiodarone, Azilsartan, Benazepril); Amlodipine/Valsartan has 2 (also Cyclosporine).
What mechanism field is on file for Lithium and Amlodipine/Valsartan?
Valsartan can make it harder for your kidneys to clear lithium from your body. This can cause lithium to build up to levels that are poisonous to your system.
Lithium's labeled portfolio outnumbers Amlodipine/Valsartan
SPL source-record counts only. This page's band is moderate · classes on file: Lithium (Mood Stabilizer); Amlodipine/Valsartan (CCB / ARB Combination).
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Azilsartan
- Benazepril
2 major · 2 moderate · 10 minor · 14 total
- Other moderate peers for Amlodipine/Valsartan
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.