Lithium and Amlodipine/Benazepril Interaction
Drug interaction information between Lithium and Amlodipine/Benazepril.
Lithium and Amlodipine/Benazepril have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Lithium and Amlodipine/Benazepril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Benazepril can make it harder for the kidneys to remove lithium from the body, causing lithium levels to rise. This increase can lead to lithium poisoning or other serious side effects.
FDA Label Information
7 DRUG INTERACTIONS • Potassium supplements/potassium-sparing diuretics: hyperkalemia ( 7.1 ) • Lithium: Increased serum lithium levels; toxicity symptoms ( 7.1 ) • Injectable gold: facial flushing, nausea, vomiting, hypotension ( 7.1 ) • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Risk of renal dysfunction, loss of antihypertensive effect ( 7.1 ) • Do not exceed doses greater than 20 mg daily of simvastatin ( 7.1 ) • mTOR inhibitors: increased risk of angioedema ( 7.1 ) • Dual inhibition of the RAS: Increased risk of renal impairment, hypotension, and hyperkalemia ( 7.1 ) • Neprilysin...
Lithium Also Interacts With
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
- Azilsartan moderate
Amlodipine/Benazepril Also Interacts With
- Amlodipine major
- Simvastatin major
- Aliskiren major
- Spironolactone moderate
- Amiloride moderate
Frequently Asked Questions
What SPL severity band is on file for Lithium + Amlodipine/Benazepril?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Amlodipine/Benazepril's 7. In the major band specifically: Lithium has 2 (also Risperidone); Amlodipine/Benazepril has 4 (also Amlodipine, Simvastatin, Aliskiren).
What mechanism field is on file for Lithium and Amlodipine/Benazepril?
Benazepril can make it harder for the kidneys to remove lithium from the body, causing lithium levels to rise. This increase can lead to lithium poisoning or other serious side effects.
Amlodipine/Benazepril carries more major-labeled pairs than Lithium
SPL source-record counts only. This page's band is major · classes on file: Lithium (Mood Stabilizer); Amlodipine/Benazepril (Calcium Channel Blocker / ACE Inhibitor Combination).
Amlodipine/Benazepril has 4 major-labeled pairs vs Lithium's 2.
4 major · 2 moderate · 1 minor · 7 total
- Other major peers for Amlodipine/Benazepril
- Amlodipine
- Simvastatin
- Aliskiren
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.