Lithium and Amiloride Interaction
Drug interaction information between Lithium and Amiloride.
Lithium and Amiloride have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lithium and Amiloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amiloride makes it harder for your kidneys to get rid of lithium. This can cause lithium to reach toxic levels in your body.
FDA Label Information
Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. Read circulars for lithium preparations before use of such concomitant therapy.
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiodarone moderate
- Amlodipine/Valsartan moderate
- Azilsartan moderate
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
- Perindopril moderate
Frequently Asked Questions
What SPL severity band is on file for Lithium + Amiloride?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Amiloride's 19. In the moderate band specifically: Lithium has 23 (also Amiodarone, Amlodipine/Valsartan, Azilsartan, Benazepril); Amiloride has 7 (also Cyclosporine, Amlodipine/Benazepril, Benazepril, Perindopril).
What mechanism field is on file for Lithium and Amiloride?
Amiloride makes it harder for your kidneys to get rid of lithium. This can cause lithium to reach toxic levels in your body.
Lithium carries more major-labeled pairs than Amiloride
SPL source-record counts only. This page's band is moderate · classes on file: Lithium (Mood Stabilizer); Amiloride (Potassium-Sparing Diuretic).
Lithium has 2 major-labeled pairs vs Amiloride's 1. This page itself is in the moderate band, not the major band.
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
1 major · 7 moderate · 11 minor · 19 total
- Other moderate peers for Amiloride
- Cyclosporine
- Amlodipine/Benazepril
- Benazepril
- Perindopril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.