Lithium and Amiloride Interaction
Drug interaction information between Lithium and Amiloride.
Lithium and Amiloride have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lithium and Amiloride. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Amiloride makes it harder for your kidneys to get rid of lithium. This can cause lithium to reach toxic levels in your body.
What To Do
These drugs should generally not be used together because of the high risk of lithium poisoning.
FDA Label Information
Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. Read circulars for lithium preparations before use of such concomitant therapy.
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiodarone moderate
- Amlodipine/Valsartan moderate
- Azilsartan moderate
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
- Perindopril moderate
Frequently Asked Questions
Can I take Lithium and Amiloride together?
This is a moderate interaction. These drugs should generally not be used together because of the high risk of lithium poisoning.
How serious is the interaction between Lithium and Amiloride?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Lithium and Amiloride interact?
Amiloride makes it harder for your kidneys to get rid of lithium. This can cause lithium to reach toxic levels in your body.
Understanding the Lithium and Amiloride Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Lithium belongs to the Mood Stabilizer class and Amiloride belongs to the Potassium-Sparing Diuretic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Amiloride makes it harder for your kidneys to get rid of lithium. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Lithium has 90 total documented interactions on file in this dataset, and Amiloride has 19. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: These drugs should generally not be used together because of the high risk of lithium poisoning. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Lithium or Amiloride based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.