Lithium and Aripiprazole Interaction
Drug interaction information between Lithium and Aripiprazole.
Lithium and Aripiprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lithium and Aripiprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not have a significant effect on each other's levels in the body. They are processed independently and do not cause a drug interaction.
FDA Label Information
7.2 Drugs Having No Clinically Important Interactions with Aripiprazole Based on pharmacokinetic studies, no dosage adjustment of aripiprazole is required when administered concomitantly with famotidine, valproate, lithium, lorazepam. Additionally, no dosage adjustment is necessary for valproate, lithium, lamotrigine, lorazepam, or sertraline when co-administered with aripiprazole [see Clinical Pharmacology (12.3)] .
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Aripiprazole Also Interacts With
- Omeprazole minor
- Sertraline minor
- Escitalopram minor
- Fluoxetine minor
- Famotidine minor
Frequently Asked Questions
What SPL severity band is on file for Lithium + Aripiprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Aripiprazole's 19. In the minor band specifically: Lithium has 65 (also Asenapine, Canagliflozin, Candesartan, Celecoxib); Aripiprazole has 19 (also Omeprazole, Sertraline, Escitalopram, Fluoxetine).
What mechanism field is on file for Lithium and Aripiprazole?
These drugs do not have a significant effect on each other's levels in the body. They are processed independently and do not cause a drug interaction.
Lithium carries more major-labeled pairs than Aripiprazole
SPL source-record counts only. This page's band is minor · classes on file: Lithium (Mood Stabilizer); Aripiprazole (Atypical Antipsychotic).
Lithium has 2 major-labeled pairs vs Aripiprazole's 0. This page itself is in the minor band, not the major band.
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Asenapine
- Canagliflozin
- Candesartan
- Celecoxib
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Aripiprazole
- Omeprazole
- Sertraline
- Escitalopram
- Fluoxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.