Amiloride and Enalapril Interaction
Drug interaction information between Amiloride and Enalapril.
Amiloride and Enalapril have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amiloride and Enalapril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can cause your body to keep more potassium, which may lead to dangerously high levels in your blood.
FDA Label Information
Potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Enalapril Also Interacts With
- Aliskiren major
- Spironolactone minor
- Hydralazine minor
- Lithium minor
- Prazosin minor
Frequently Asked Questions
What SPL severity band is on file for Amiloride + Enalapril?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Enalapril's 16. In the minor band specifically: Amiloride has 11 (also Indomethacin, Amlodipine/Valsartan, Hydrochlorothiazide, Hydrochlorothiazide); Enalapril has 15 (also Spironolactone, Hydralazine, Lithium, Prazosin).
What mechanism field is on file for Amiloride and Enalapril?
Both of these medications can cause your body to keep more potassium, which may lead to dangerously high levels in your blood.
Amiloride's labeled portfolio outnumbers Enalapril
SPL source-record counts only. This page's band is minor · classes on file: Amiloride (Potassium-Sparing Diuretic); Enalapril (ACE Inhibitor).
1 major · 7 moderate · 11 minor · 19 total
- Other minor peers for Amiloride
- Indomethacin
- Amlodipine/Valsartan
- Hydrochlorothiazide
- Hydrochlorothiazide
1 major · 0 moderate · 15 minor · 16 total
- Other minor peers for Enalapril
- Spironolactone
- Hydralazine
- Lithium
- Prazosin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.