What the FDA labels say about taking them together
Enalapril and lithium
Enalapril's FDA label of January 23, 2026 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name enalapril. The enalapril label: “Lithium toxicity has been reported in patients receiving enalapril and lithium concomitantly which was generally reversible.”
Check it at the source: the enalapril FDA label on DailyMed (effective January 23, 2026, Bausch Health US LLC); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the enalapril label say about lithium?
Enalapril label, drug interactionsLithium Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors.
Epaned label (Azurity Pharmaceuticals, Inc., December 16, 2025), drug interactionsLithium toxicity has been reported in patients receiving enalapril and lithium concomitantly which was generally reversible.
Source: FDA drug label (Epaned, NDA208686), Azurity Pharmaceuticals, Inc., effective December 16, 2025 (SPL set e6dbda02-779e-420c-893d-d0fea09432be), via openFDA
Source: FDA drug label (Vasotec), Bausch Health US LLC, effective January 23, 2026 (SPL set 39631f1f-5d19-43c1-b504-bf56d991ed97), via openFDA; the full label on DailyMed
What does the lithium label say about enalapril?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name enalapril in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Enalapril | Lithium | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure | Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0664 per tablet 10 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once