Enalapril and Lithium Interaction
Drug interaction information between Enalapril and Lithium.
Enalapril and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Enalapril and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Enalapril can cause your body to lose sodium, which makes it harder for your kidneys to get rid of lithium. This can cause lithium to build up to toxic levels in your blood.
FDA Label Information
Lithium Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors. A few cases of lithium toxicity have been reported in patients receiving concomitant enalapril maleate and lithium and were reversible upon discontinuation of both drugs. It is recommended that serum lithium levels be monitored frequently if enalapril is administered concomitantly with lithium.
Enalapril Also Interacts With
- Aliskiren major
- Spironolactone minor
- Hydralazine minor
- Prazosin minor
- Methyldopa minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Enalapril + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Enalapril's 16. In the minor band specifically: Enalapril has 15 (also Spironolactone, Hydralazine, Prazosin, Methyldopa); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Enalapril and Lithium?
Enalapril can cause your body to lose sodium, which makes it harder for your kidneys to get rid of lithium. This can cause lithium to build up to toxic levels in your blood.
Lithium carries more major-labeled pairs than Enalapril
SPL source-record counts only. This page's band is minor · classes on file: Enalapril (ACE Inhibitor); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Enalapril's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 15 minor · 16 total
- Other minor peers for Enalapril
- Spironolactone
- Hydralazine
- Prazosin
- Methyldopa
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.