Enalapril and Aliskiren Interaction
Drug interaction information between Enalapril and Aliskiren.
Enalapril and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Enalapril and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs work on the same system to lower blood pressure, which can lead to dangerously low blood pressure or kidney damage.
FDA Label Information
Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not coadminister aliskiren with enalapril maleate in patients with diabetes. Avoid use of aliskiren with enalapril maleate in patients with renal impairment (GFR <60 mL/min).
Enalapril Also Interacts With
- Spironolactone minor
- Hydralazine minor
- Lithium minor
- Prazosin minor
- Methyldopa minor
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Frequently Asked Questions
What SPL severity band is on file for Enalapril + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Enalapril's 16. In the major band specifically: Enalapril has 1; Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Azilsartan, Benazepril).
What mechanism field is on file for Enalapril and Aliskiren?
Both drugs work on the same system to lower blood pressure, which can lead to dangerously low blood pressure or kidney damage.
Aliskiren carries more major-labeled pairs than Enalapril
SPL source-record counts only. This page's band is major · classes on file: Enalapril (ACE Inhibitor); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Enalapril's 1.
1 major · 0 moderate · 15 minor · 16 total
Enalapril has no other major-band peer in this dataset besides Aliskiren.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.