Amiloride and Hydrochlorothiazide Interaction
Drug interaction information between Amiloride and Hydrochlorothiazide.
Amiloride and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amiloride and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can stop your kidneys from getting rid of potassium. This can cause the amount of potassium in your blood to rise to unsafe levels.
FDA Label Information
Use of lisinopril with potassium-sparing diuretics (e.g., spironolactone, eplerenone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Lisinopril minor
- Losartan minor
- Hydrochlorothiazide minor
- Spironolactone minor
Frequently Asked Questions
What SPL severity band is on file for Amiloride + Hydrochlorothiazide/Lisinopril?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Hydrochlorothiazide's 13. In the minor band specifically: Amiloride has 11 (also Indomethacin, Amlodipine/Valsartan, Enalapril, Hydrochlorothiazide); Hydrochlorothiazide has 12 (also Lisinopril, Losartan, Hydrochlorothiazide, Spironolactone).
What mechanism field is on file for Amiloride and Hydrochlorothiazide/Lisinopril?
Both of these drugs can stop your kidneys from getting rid of potassium. This can cause the amount of potassium in your blood to rise to unsafe levels.
Amiloride's labeled portfolio outnumbers Hydrochlorothiazide
SPL source-record counts only. This page's band is minor · classes on file: Amiloride (Potassium-Sparing Diuretic); Hydrochlorothiazide (Thiazide Diuretic / ACE Inhibitor Combination).
1 major · 7 moderate · 11 minor · 19 total
- Other minor peers for Amiloride
- Indomethacin
- Amlodipine/Valsartan
- Enalapril
- Hydrochlorothiazide
1 major · 0 moderate · 12 minor · 13 total
- Other minor peers for Hydrochlorothiazide
- Lisinopril
- Losartan
- Hydrochlorothiazide
- Spironolactone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.