Amiloride and Amlodipine/Valsartan Interaction
Drug interaction information between Amiloride and Amlodipine/Valsartan.
Amiloride and Amlodipine/Valsartan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amiloride and Amlodipine/Valsartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause your body to keep too much potassium, which can lead to high levels in your blood.
FDA Label Information
Valsartan Agents Increasing Serum Potassium: Concomitant use of valsartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine.
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Aliskiren major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine minor
Frequently Asked Questions
What SPL severity band is on file for Amiloride + Amlodipine/Valsartan?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Amlodipine/Valsartan's 14. In the minor band specifically: Amiloride has 11 (also Indomethacin, Enalapril, Hydrochlorothiazide, Hydrochlorothiazide); Amlodipine/Valsartan has 10 (also Amlodipine, Hydrochlorothiazide, Spironolactone, Valsartan).
What mechanism field is on file for Amiloride and Amlodipine/Valsartan?
Both drugs can cause your body to keep too much potassium, which can lead to high levels in your blood.
Amlodipine/Valsartan carries more major-labeled pairs than Amiloride
SPL source-record counts only. This page's band is minor · classes on file: Amiloride (Potassium-Sparing Diuretic); Amlodipine/Valsartan (CCB / ARB Combination).
Amlodipine/Valsartan has 2 major-labeled pairs vs Amiloride's 1. This page itself is in the minor band, not the major band.
1 major · 7 moderate · 11 minor · 19 total
- Other minor peers for Amiloride
- Indomethacin
- Enalapril
- Hydrochlorothiazide
- Hydrochlorothiazide
2 major · 2 moderate · 10 minor · 14 total
- Other minor peers for Amlodipine/Valsartan
- Amlodipine
- Hydrochlorothiazide
- Spironolactone
- Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.