Enalapril and Hydralazine Interaction
Drug interaction information between Enalapril and Hydralazine.
Enalapril and Hydralazine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Enalapril and Hydralazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two blood pressure medicines work in different ways to relax your blood vessels and have not been shown to cause harmful interactions when used together.
FDA Label Information
Other Cardiovascular Agents Enalapril maleate has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine, prazosin and digoxin without evidence of clinically significant adverse interactions.
Enalapril Also Interacts With
- Aliskiren major
- Spironolactone minor
- Lithium minor
- Prazosin minor
- Methyldopa minor
Frequently Asked Questions
What SPL severity band is on file for Enalapril + Hydralazine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Enalapril has 16 labeled pairs on file vs Hydralazine's 3. In the minor band specifically: Enalapril has 15 (also Spironolactone, Lithium, Prazosin, Methyldopa); Hydralazine has 3 (also Alosetron, Pindolol).
What mechanism field is on file for Enalapril and Hydralazine?
These two blood pressure medicines work in different ways to relax your blood vessels and have not been shown to cause harmful interactions when used together.
Enalapril carries more major-labeled pairs than Hydralazine
SPL source-record counts only. This page's band is minor · classes on file: Enalapril (ACE Inhibitor); Hydralazine (Vasodilator).
Enalapril has 1 major-labeled pair vs Hydralazine's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 15 minor · 16 total
- Other minor peers for Enalapril
- Spironolactone
- Lithium
- Prazosin
- Methyldopa
0 major · 0 moderate · 3 minor · 3 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.