Enalapril and Spironolactone Interaction
Drug interaction information between Enalapril and Spironolactone.
Enalapril and Spironolactone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Enalapril and Spironolactone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can cause your body to hold onto potassium instead of flushing it out. This can lead to dangerously high levels of potassium in your blood.
FDA Label Information
Potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Enalapril Also Interacts With
- Aliskiren major
- Hydralazine minor
- Lithium minor
- Prazosin minor
- Methyldopa minor
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Enalapril + Spironolactone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Spironolactone has 23 labeled pairs on file vs Enalapril's 16. In the minor band specifically: Enalapril has 15 (also Hydralazine, Lithium, Prazosin, Methyldopa); Spironolactone has 14 (also Digoxin, Cholestyramine, Amlodipine/Valsartan, Felodipine).
What mechanism field is on file for Enalapril and Spironolactone?
Both of these medications can cause your body to hold onto potassium instead of flushing it out. This can lead to dangerously high levels of potassium in your blood.
Enalapril carries more major-labeled pairs than Spironolactone
SPL source-record counts only. This page's band is minor · classes on file: Enalapril (ACE Inhibitor); Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist).
Enalapril has 1 major-labeled pair vs Spironolactone's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 15 minor · 16 total
- Other minor peers for Enalapril
- Hydralazine
- Lithium
- Prazosin
- Methyldopa
0 major · 9 moderate · 14 minor · 23 total
- Other minor peers for Spironolactone
- Digoxin
- Cholestyramine
- Amlodipine/Valsartan
- Felodipine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.