Prescription medication · Potassium-Sparing Diuretic
amiloride
Also sold as Midamor. Amiloride treats high blood pressure and heart failure.
Data updated 2026-05-15
- 834
- FDA reportsRarely reported
- 19
- InteractionsSeveral interactions
- $0.17
- Generic price (NADAC)
What the data shows
amiloride (Midamor) is a prescription Potassium-Sparing Diuretic, among the least-reported drugs the FDA tracks (834 FDA reports), with 19 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
amiloride (Midamor) is a prescription Potassium-Sparing Diuretic. Amiloride treats high blood pressure and heart failure.
Amiloride is a water pill that helps your body hold onto potassium. It is often used with other water pills to prevent low potassium levels.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$0.17/unit
Generic Available
Yes (3 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Amiloride treats high blood pressure and heart failure.
Common side effects
Headache, Nausea, Loss of appetite
Key warnings
Amiloride can cause high potassium levels, which can be dangerous.
The sections below are summarized in plain English from amiloride's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Amiloride blocks sodium channels in your kidneys. This action reduces the amount of potassium lost in your urine. This helps to maintain or increase potassium levels in your body.
How to Take It
Take amiloride with food. Your doctor will tell you how much to take, usually starting with one 5 mg tablet daily. The dose may be increased to 10 mg per day if needed. Do not take more than two 5 mg tablets daily unless your doctor tells you to.
This is a plain-language summary of amiloride's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if amiloride can harm an unborn baby or pass into breast milk.
This is a plain-language summary of amiloride's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
This is a plain-language summary of amiloride's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Store at room temperature between 59°F and 86°F in a tightly closed, light-resistant container.
Side Effects (from patient reports)
Based on 834 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for amiloride, by number of reports
- Shortness of breath
Shortness of breath
69 reports
- Diarrhea
Diarrhea
57 reports
- Feeling sick to your stomach
Feeling sick to your stomach
49 reports
- Throwing up
Throwing up
39 reports
- Tiredness
Tiredness
37 reports
- Feeling unwell
Feeling unwell
37 reports
- Falling down
Falling down
36 reports
- Confusion
Confusion
33 reports
- Interaction with another medicine
Interaction with another medicine
33 reports
- Headache
Headache
32 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for amiloride each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where amiloride sits
amiloride has more FDA adverse-event reports than 6% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is amiloride; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 834 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
834
Reports Mentioning Death
62
7.4% of reports — not proof of cause
Hospitalization Reports
384
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DYSPNOEA | 69 |
| 2 | DIARRHOEA | 57 |
| 3 | NAUSEA | 49 |
| 4 | VOMITING | 39 |
| 5 | FATIGUE | 37 |
| 6 | MALAISE | 37 |
| 7 | FALL | 36 |
| 8 | CONFUSIONAL STATE | 33 |
| 9 | DRUG INTERACTION | 33 |
| 10 | HEADACHE | 32 |
| 11 | HYPERKALAEMIA | 31 |
| 12 | PRURITUS | 29 |
| 13 | RENAL FAILURE ACUTE | 29 |
| 14 | ABDOMINAL PAIN | 28 |
| 15 | ASTHENIA | 27 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Amiloride can cause high potassium levels, which can be dangerous. You should not take this medicine if you already have high potassium, kidney problems, or are taking other potassium-sparing diuretics or potassium supplements. Your doctor should check your potassium levels regularly.
Known Drug Interactions
7 DRUG INTERACTIONS Triamterene and amiloride: Concomitant use is contraindicated (7.1) Renin-angiotensin-aldosterone inhibitors: Monitor for hyperkalemia (7.2) Nonsteroidal anti-inflammatory drugs: Monitor for hyperkalemia (7.3) 7.1 Triamterene or amiloride Use with triamterene or amiloride can produce severe hyperkalemia.
Mechanism: Both of these medicines increase the amount of potassium in your blood, and taking them together can cause potassium levels to become dangerously high.
What to do: Do not take these two medications together as the combination is restricted.
Drug Interactions When amiloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, an angiotensin II receptor antagonist, cyclosporine or tacrolimus, the risk of hyperkalemia may be increased.
Mechanism: Both of these medications can cause potassium levels in your blood to rise. Taking them together increases the risk of having too much potassium, which can be dangerous.
What to do: Your doctor should monitor your blood potassium levels closely while you are taking both drugs.
Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. Read circulars for lithium preparations before use of such concomitant therapy.
Mechanism: Amiloride makes it harder for your kidneys to get rid of lithium. This can cause lithium to reach toxic levels in your body.
What to do: These drugs should generally not be used together because of the high risk of lithium poisoning.
Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements can increase the risk of hyperkalemia. Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements can increase the risk of hyperkalemia.
Mechanism: Both of these medications can cause the body to keep too much potassium instead of passing it through urine. This can lead to a dangerous buildup of potassium in your blood.
What to do: Your doctor should monitor your potassium levels closely while you are taking these medications together.
Hyperkalemia Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) can increase the risk of hyperkalemia.
Mechanism: These two drugs both prevent the kidneys from flushing out potassium. Taking them together increases the risk that your potassium levels will become too high.
What to do: You should have regular blood tests to check your potassium levels if you are prescribed both medications.
This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.
Common Questions
Can I take amiloride alone?
What should I do if I experience side effects?
Can I take potassium supplements with amiloride?
Will amiloride affect my other medications?
How often will my potassium levels be checked?
Can I drink alcohol while taking amiloride?
What if I have kidney problems?
Can amiloride cause dehydration?
Does amiloride affect blood sugar?
Can I drive or operate machinery while taking amiloride?
What are the common side effects of amiloride?
Does amiloride interact with other medications?
What drug class is amiloride?
Is amiloride safe during pregnancy?
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What the FDA Data Shows for amiloride
The FDA label for amiloride (sold under brand names such as Midamor) classifies it as a prescription-only medication in the Potassium-Sparing Diuretic class. Amiloride treats high blood pressure and heart failure. Official labeling lists 9 commonly reported side effects, including Headache, Nausea, Loss of appetite.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 834 voluntary reports. The database also lists 19 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $0.17.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: November 28, 2023
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages