Amiloride and Indomethacin Interaction
Drug interaction information between Amiloride and Indomethacin.
Amiloride and Indomethacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amiloride and Indomethacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can cause potassium levels in your blood to rise to unsafe levels and may affect how your kidneys work.
FDA Label Information
Since indomethacin and potassium-sparing diuretics, including amiloride HCl, may each be associated with increased serum potassium levels, the potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently.
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Amiloride + Indomethacin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Indomethacin has 35 labeled pairs on file vs Amiloride's 19. In the minor band specifically: Amiloride has 11 (also Amlodipine/Valsartan, Enalapril, Hydrochlorothiazide, Hydrochlorothiazide); Indomethacin has 30 (also Meloxicam, Aspirin, Diclofenac, Cyclosporine).
What mechanism field is on file for Amiloride and Indomethacin?
Both of these drugs can cause potassium levels in your blood to rise to unsafe levels and may affect how your kidneys work.
Amiloride carries more major-labeled pairs than Indomethacin
SPL source-record counts only. This page's band is minor · classes on file: Amiloride (Potassium-Sparing Diuretic); Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Amiloride has 1 major-labeled pair vs Indomethacin's 0. This page itself is in the minor band, not the major band.
1 major · 7 moderate · 11 minor · 19 total
- Other minor peers for Amiloride
- Amlodipine/Valsartan
- Enalapril
- Hydrochlorothiazide
- Hydrochlorothiazide
0 major · 5 moderate · 30 minor · 35 total
- Other minor peers for Indomethacin
- Meloxicam
- Aspirin
- Diclofenac
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.